The week's co-ordinator Elaine Budd said: "This is a fantastic opportunity to shout about the wonderful projects and relationships that have been built during the past six years."
The week will start with Link members meeting the British High Commissioner to Ghana, Dr Nick Westcott, and Professor Kwaku Danso-Boafo, the Ghanaian High Commissioner, while students from Devonport High School for Girls will give the Blue Mile an African twist by carrying a container of water on their heads.
The Ghanaian High Commissioner will attend a dinner with the Lord Mayor on Wednesday city and Link representatives.
Visitors will also attend an exhibition to celebrate Ghana Week, in the Roland Levinsky Building at the University of Plymouth.
The week will also see a number of performances by West African music and dance duo Sabey.
Formed in 2008, Sabey is spiced with influences from around the world, creating a unique and intricate blend of sound, energy and infectious rhythm.
One of the Link's successes being celebrated during Ghana Week is Operation Hernia, set up by surgeons at Derriford Hospital.
Since 2005, the charitable link has performed more than 2,500 hernia operations in Ghana.
On Tuesday there is a welcome for visiting Ghanaian dignitaries at Marjon with a Link exhibition Big Arts Day at the Plymouth Pavilions.
Wednesday sees the performance by Sabey in Devonport Park as part of The Big Arts Festival Art in the Community. And on Thursday, they perform at University of Plymouth's Roland Levinsky Building.
On Saturday, July 10, there is a Link-supporting World Music Festival at Saltram House near Plympton.